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VIa Toronto (for I-75 and points west)
- Follow ON-400 from Toronto north to Barrie, then ON-11 to North Bay
- Take ON-63 to the Quebec border and R-101, OR stay on ON-11 until New Liskeard and take ON-65 to cross the border and reach R-101.
- R-101 north to R-117.
- R-117 east to R-109
- R-109 north to Matagami via Amos.
Via Montreal (for points east of I-87)
- I-87 turns into A-15 at the NY/QC border
- Follow A-15 through Montreal
- A-15 uses a difficult exit to cross the St. Lawrence River over the Champlain Bridge with A-20/A-10, and later jogs eastward on A-40, including a left-exit.
- An hour north of Montreal, A-15 becomes R-117
- Follow R-117 to Val d'Or, turning north on R-111.
- Travel north on R-111 to Amos, turn north on R-109, which heads to Matagami
Possible route for points between I-75 and I-87 (or points between Toronto and Montreal):
- In the US, get to I-81 via the Quickway or the NYS Thruway
- Follow I-81 north to the border at the Thousand Islands Bridge (toll)
- Then, ON-401 east to ON-416
- ON-416 to its terminus at ON-417
- Take ON-417 east, exit at Nicholas St. and follow the signage to A-5 (Quebec) through downtown Ottawa
- Follow A-5 until it ends and becomes R-105.
- R-105 to R-117, then follow the Montreal directions (117, 111, 109).